John C. McAuliffe, M.D. Ph.D.

Clinical Member of the Albert Einstein Cancer Center, Tumor Microenvironment and Metastasis Program

Member, Cancer Dormancy and Tumor Microenvironment Institute

Member, New York Pathology Oncology Group

Chair, Neuroendocrine Tumor Board, Montefiore-Einstein Center for Cancer Care

Chair, Upper Gastrointestinal Tumor Board, Montefiore-Einstein Center for Cancer Care

Director of the Surgical Faculty Advisors for the T32 Fellowship "Training of Surgeons in Basic and Translational Research"

Assistant Site-Director at Jack D. Weiler Hospital for the Albert Einstein College of Medicine Surgery Clerkship

 Dr. John McAuliffe is a surgeon-scientist in the Department of Surgery. He joined the Montefiore-Einstein surgical oncology team in 2016. He recieved an MD/PhD degree at UT Houston and MD Anderson.  He then went to UAB for surgical training followed by Memorial Sloan Kettering Cancer Center for surgical oncology fellowship.

His clinical practice includes Pancreatic, Biliary, Neuroendocrine, Thyroid, and Adrenal benign and malignant diseases. 

His laboratory focuses on the mechanisms of metastasis in pancreatic adenocarcinoma and Tie2 signaling.   He utilizes transgenic mouse models, cell culture, human samples, and intravital microscopy to evaluate tumor associated macrophage and cancer cell signaling through Tie2 in cancer cell invasion, migration, intravasation, epithelial-mesenchymal transition, stemness, and dormancy in pancreatic adenocarcinoma.  Dr. McAuliffe has observed TMEM doorways in human and mouse pancreatic cancer.  Treatment of mice harboring pancreatic cancer had a decrease in circulating tumor cells after Tie2 blockade.  These data suggest a conserved mechanism of intravasation in adenocarcinomas.  Dr. McAuliffe's laboratory seeks to better understand this phenomenon with the ultimate goal of translation to clinical trial.

He has recieved funding from the National Cancer Institute, the Nikki Mitchell Foundation and Pancreas Club, and Deciphera Therapeutics.  He collaborates with leaders in the field including Ben Z. Stanger, Sunil Hingorani, John Condeelis, Nicole Panarelli, Maja Oktay, David Entenberg, and Claudia Gravekamp.

Dr. McAuliffe mentors a T32 surgical research fellow, a research assistant, and is the Director of Surgical Faculty Advisors for the Montefiore-Einstein Department of Surgery T32 Fellowship "Training Surgeons in Basic and Translational Research."

His clinical research focuses on outcomes of gallbladder disease, and calcium metabolism disparity.